Domain architectures and conserved gene neighborhoods of ASRAH homologs. Gene neighborhoods are labeled by the organisms or taxonomic groups in which they are detected, of which the prototype species is depicted in bold letters. Complete descriptions for the gene abbreviations used in gene neighborhood and operon depictions are provided in the key below. The signal peptides in the actinomycete protein with two ASRAH domains are accompanied by a lipobox-like cysteine. Colors denote different functional classes, e.g. red represents enzymes or enzymatic domains, orange transporters, purple sensors. For a complete list of architectures and gene neighborhoods see Additional file 1.