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Table 1 Percentage of protein sequence identity for proteins of the BMP/GDF family, between human and mouse and between human and chicken, for the total protein and the relevant signal peptide.

From: Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape

 

H. sapiens versus M. musculus % sequence identity

H. sapiens versus G. gallus % sequence identity

 

Whole length

Signal peptide

Whole length

Signal peptide

AMH

74.0

40.0

45.1

43.3

BMP2

92.4

93.3

81.3

66.7

BMP3

81.1

63.3

67.2

36.7

BMP4

97.5

100.0

85.3

90.0

BMP5

93.2

86.7

92.7

70.0

BMP6

91.9

96.7

85.1

16.7

BMP7

97.7

100.0

91.4

30.0

BMP9 (GDF2)

80.4

53.3

61.8

30.0

BMP10

85.5

73.3

74.7

46.7

BMP14(GDF5)

92.3

90.0

70.6

33.3

BMP15

64.2

60.0

47.0

13.3

GDF3

71.1

33.3

48.9

33.3

MSTN (GDF8)

96.3

80.0

92.0

53.3

GDF9

74.1

66.7

589

20.0

  1. The percentage of sequence identity for the signal peptide was calculated for the first 30 amino acid in human sequences, excluding gaps. Notice that there are several possibilities, ranging from strong conservation in the three species including the signal peptide (BMP4), passing through cases of overall conservation excluding the signal peptide (GDF8), to cases of rather low conservation in the three species (BMP15).