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Table 3 Predicted new TAS

From: Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

Toxin (T)

Antitoxin (AT)

Comment

MNT

HEPN

MNT – minimal nucleotidyltransferase, possible toxin; HEPN – possible substrate binding domain; Structure solved (MNT: 1no5 and HEPN: 1o3u and 1jog). Molecular mechanism unknown.

PIN

COG2442

Structure of AT is solved (PDB:2ga1):DNA/RNA-binding 3-helical bundle.

PIN

COG2880

Structure of AT is solved (PDB:2nwt); related to AbrB superfamily

PIN

COG1753

AT – RHH (RHH); Specific for archaea

PIN

MerR

AT: truncated MerR

COG4679 subfamily

COG5606 HTH

AT – predicted HTH domain; T – predicted RelE superfamily protein

RelE

MJ1172 RHH

Specific for methanogens; AT – predicted RHH superfamily protein

MazF

XF1863

No prediction for AT

Fic/Doc

YhfG

AT – is predicted DNA-binding protein; Specific for enteroproteobacteria

SMa0917 subfamily

PHD

T – predicted MazF superfamily protein; Molecular mechanism is likely the same as for MazF toxin

COG2929

COG5304 and COG3514

Families

AT: predicted RHH family protein; Molecular mechanism unknown.

DUF397

Xre/cro HTH

T – no prediction; molecular mechanism unknown.

COG2856

Xre/cro HTH

T – predicted Zn-dependent protease. Often fused to AT domain. Frequent association with RelE and PIN toxins

COG5654

COG5642 subfamily

AT – xre family HTH; T – RES domain; Molecular mechanism unknown.

YgiU/MqsR

Xre/cro HTH

T: motility quorum-sensing regulator mqsR [75]

GNAT

Xre/cro HTH

The closest characterized GNAT family acetyltrasferase is involved in antibiotic resistance [88]

GNAT

RHH

T – is GNAT family acetyltrasferase

Bro

Xre/cro HTH

 

COG3832

ArsR-like HTH

T – Cyclase/dehydratase family protein. (PDB: 1xuv) START domain superfamily

  1. New toxins and antitoxins predicted in this work are shown in bold type