Skip to main content
Figure 1 | Biology Direct

Figure 1

From: Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors

Figure 1

The conserved motifs of exonuclease and polymerase catalytic domains of active B-family polymerases compared to inactivated C-terminal domains of polymerases ε. The motifs are represented as four sequence LOGOs, from top to bottom: all active Exo domains of B-family polymerases from the alignment in Additional File 1 (archaeal, proteobacterial, and eukaryotic Polδ and N-terminal domain of Polε); inactivated C-terminal domain of Polε; all active Pol domains; inactivated C-terminal domain of Polε. The motifs that contribute to the active centers are denoted Exo I-III and Region I-III for the Exo and Pol domains, respectively, and the catalytic residues are shown by #.

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us