Table 7 NGF signaling network.
From: Activating and inhibiting connections in biological network dynamics
Upstream node | Downstream node | Sign of interaction |
|---|---|---|
Ras | Raf | + |
Raf | MEK1/2 | + |
MEK1/2 | Erk1/Erk2 | + |
Erk1/Erk2 | Rsk | + |
Rsk | CREB | + |
CREB | FasL/Bcl-2/Bax/Egr-1 mRNA | + |
p38 | FasL/Bcl-2/Bax/Egr-1 mRNA | + |
Akt1/2 | FasL/Bcl-2/Bax/Egr-1 mRNA | + |
Forkhead | FasL/Bcl-2/Bax/Egr-1 mRNA | + |
NFκB | FasL/Bcl-2/Bax/Egr-1 mRNA | + |
Trk receptor | PLCγ | + |
PLCγ | IP3/DAG complex | + |
IP3/DAG complex | PKCδ | + |
PKCδ | MEK1/2 | + |
Frs2/Crk/DOCK-180/SH2B/Grb2 complex | Rac | + |
Trk receptor | IRS-1 | + |
IRS-1 | Shc/Grb2/SOS/Gab/PI3k complex | + |
Shc/Grb2/SOS/Gab/PI3k complex | 1 | + |
Shc/Grb2/SOS/Gab/PI3k complex | Akt1/2 | + |
PDKs | Akt1/2 | + |
Akt1/2 | p38 | - |
Akt1/2 | Forkhead | - |
Akt1/2 | NFκB | + |
Akt1/2 | BAD/Bcl-2 complex | + |
BAD/Bcl-2 complex | Bad/14-3-3 complex | + |
Ras | Shc/Grb2/SOS/Gab/PI3k complex | + |
Shc/Grb2/SOS/Gab/PI3k complex | MEK1/2 | + |
Trk receptor | Frs2/Crk/DOCK-180/SH2B/Grb2 complex | + |