Skip to main content

Table 7 NGF signaling network.

From: Activating and inhibiting connections in biological network dynamics

Upstream node Downstream node Sign of interaction
Ras Raf +
Raf MEK1/2 +
MEK1/2 Erk1/Erk2 +
Erk1/Erk2 Rsk +
Rsk CREB +
CREB FasL/Bcl-2/Bax/Egr-1 mRNA +
p38 FasL/Bcl-2/Bax/Egr-1 mRNA +
Akt1/2 FasL/Bcl-2/Bax/Egr-1 mRNA +
Forkhead FasL/Bcl-2/Bax/Egr-1 mRNA +
NFκB FasL/Bcl-2/Bax/Egr-1 mRNA +
Trk receptor PLCγ +
PLCγ IP3/DAG complex +
IP3/DAG complex PKCδ +
PKCδ MEK1/2 +
Frs2/Crk/DOCK-180/SH2B/Grb2 complex Rac +
Trk receptor IRS-1 +
IRS-1 Shc/Grb2/SOS/Gab/PI3k complex +
Shc/Grb2/SOS/Gab/PI3k complex 1 +
Shc/Grb2/SOS/Gab/PI3k complex Akt1/2 +
PDKs Akt1/2 +
Akt1/2 p38 -
Akt1/2 Forkhead -
Akt1/2 NFκB +
Akt1/2 BAD/Bcl-2 complex +
BAD/Bcl-2 complex Bad/14-3-3 complex +
Ras Shc/Grb2/SOS/Gab/PI3k complex +
Shc/Grb2/SOS/Gab/PI3k complex MEK1/2 +
Trk receptor Frs2/Crk/DOCK-180/SH2B/Grb2 complex +
  1. This table shows the connections that comprise the topology of the NGF signaling network.