Table 6 WNT/β-catenin signaling network.
From: Activating and inhibiting connections in biological network dynamics
Upstream node | Downstream node | Sign of interaction |
|---|---|---|
WNT | WNT-Frizzled complex | + |
DKK | WNT-Frizzled complex | - |
WIF-1 | WNT-Frizzled complex | - |
WNT-Frizzled complex | pDSH | + |
NAKED | pDSH | - |
pDSH | PP2A | + |
pDSH | pAXIN-pAPC-pβ-catenin complex | - |
CK-I/CK-II complex | pDSH | + |
DSH | pDSH | + |
PP2A | pAXIN | + |
PP2A | pβ-catenin | + |
pAXIN-pAPC-pβ-catenin complex | pAXIN | + |
pAXIN-pAPC-pβ-catenin complex | β-catenin | + |
pAXIN-pAPC-pβ-catenin complex | pβ-catenin/β-TRCP complex | + |
pβ-catenin | pβ-catenin/β-TRCP complex | + |
β-TRCP | pβ-catenin/β-TRCP complex | + |
Ubiquitin pathway | pβ-catenin/Ubiquitin complex | + |
pβ-catenin/β-TRCP complex | pβ-catenin/Ubiquitin complex | + |
pβ-catenin/Ubiquitin complex | β-catenin fragments | + |
Proteasome | β-catenin fragments | + |
GSK3B | pAXIN-pAPC-pβ-catenin complex | + |
FRAT1 | pAXIN-pAPC-pβ-catenin complex | - |
AXIN/APC/β-catenin complex | pAXIN-pAPC-pβ-catenin complex | + |
AXIN/APC/β-catenin complex | β-catenin/GROUCHO/Smad4 complex | + |
β-catenin/GROUCHO/Smad4 complex | c-MYC/CYCLIN D1/PPAR d complex | + |
GROUCHO complex | c-MYC/CYCLIN D1/PPAR d complex | - |
HDAC | GROUCHO complex | + |
GROUCHO complex | β-catenin/GROUCHO/Smad4 complex | + |
TAK1/TAB1 complex | NLK | + |
NLK | β-catenin/GROUCHO/Smad4 complex | - |