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Table 6 WNT/β-catenin signaling network.

From: Activating and inhibiting connections in biological network dynamics

Upstream node Downstream node Sign of interaction
WNT WNT-Frizzled complex +
DKK WNT-Frizzled complex -
WIF-1 WNT-Frizzled complex -
WNT-Frizzled complex pDSH +
NAKED pDSH -
pDSH PP2A +
pDSH pAXIN-pAPC-pβ-catenin complex -
CK-I/CK-II complex pDSH +
DSH pDSH +
PP2A pAXIN +
PP2A pβ-catenin +
pAXIN-pAPC-pβ-catenin complex pAXIN +
pAXIN-pAPC-pβ-catenin complex β-catenin +
pAXIN-pAPC-pβ-catenin complex pβ-catenin/β-TRCP complex +
pβ-catenin pβ-catenin/β-TRCP complex +
β-TRCP pβ-catenin/β-TRCP complex +
Ubiquitin pathway pβ-catenin/Ubiquitin complex +
pβ-catenin/β-TRCP complex pβ-catenin/Ubiquitin complex +
pβ-catenin/Ubiquitin complex β-catenin fragments +
Proteasome β-catenin fragments +
GSK3B pAXIN-pAPC-pβ-catenin complex +
FRAT1 pAXIN-pAPC-pβ-catenin complex -
AXIN/APC/β-catenin complex pAXIN-pAPC-pβ-catenin complex +
AXIN/APC/β-catenin complex β-catenin/GROUCHO/Smad4 complex +
β-catenin/GROUCHO/Smad4 complex c-MYC/CYCLIN D1/PPAR d complex +
GROUCHO complex c-MYC/CYCLIN D1/PPAR d complex -
HDAC GROUCHO complex +
GROUCHO complex β-catenin/GROUCHO/Smad4 complex +
TAK1/TAB1 complex NLK +
NLK β-catenin/GROUCHO/Smad4 complex -
  1. This table shows the connections that comprise the topology of the WNT/β-catenin signaling network.