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Table 5 Notch signaling network.

From: Activating and inhibiting connections in biological network dynamics

Upstream node Downstream node Sign of interaction
Fringe Notch +
Dvl Notch -
Numb Notch -
Notch Deltex +
γ-Secretase complex Notch +
TACE Notch +
Serrate Notch -
Delta Notch +
Notch CSL +
SKIP CSL +
MAML/HATs CSL +
CSL O DNA +
Co-repressor complex CSL -
O DNA Hes1/5 +
O DNA PreTα +
  1. This table shows the connections that comprise the topology of the Notch signaling network.