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Table 5 Notch signaling network.

From: Activating and inhibiting connections in biological network dynamics

Upstream node

Downstream node

Sign of interaction

Fringe

Notch

+

Dvl

Notch

-

Numb

Notch

-

Notch

Deltex

+

γ-Secretase complex

Notch

+

TACE

Notch

+

Serrate

Notch

-

Delta

Notch

+

Notch

CSL

+

SKIP

CSL

+

MAML/HATs

CSL

+

CSL

O DNA

+

Co-repressor complex

CSL

-

O DNA

Hes1/5

+

O DNA

PreTα

+

  1. This table shows the connections that comprise the topology of the Notch signaling network.