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Figure 4 | Biology Direct

Figure 4

From: Functional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'–5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch

Figure 4

A proposed "active site switch" mode for MAEL domain function evolution. The cartoon drawing of protein structure is shown. The α helices are shown in pink, β sheets in yellow and loops in white. The DnaQ-H specific residues (DEDHD) are highlighted in blue, whereas MAEL specific residues (EHHCHC) are highlighted in red. Red cloud and green cloud indicate DnaQ-H active site and MAEL-specific active site, respectively.

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