Skip to main content

Table 1 The three-residue grip model of susceptibility to immune mediated diabetes

From: A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes

allele

β9

β37

Non-Asp β57

score

T1D

DRB1*0101

Hydrophobic W

Polar S

No

1

No

DRB1*0301

Polar E

Polar N

No

2

Yes

DRB1*0401

Polar E

Polar Y

No

2

Yes

DRB1*0402

Polar E

Polar Y

No

2

Yes

DRB1*0403

Polar E

Polar Y

No

2

No

DRB1*0404

Polar E

Polar Y

No

2

Yes

DRB1*0405

Polar E

Polar Y

Yes S

3

Yes

DRB1*0406

Polar E

Polar S

No

2

No

DRB1*0407

Polar E

Polar Y

No

2

Yes

DRB1*0408

Polar E

Polar E

No

2

Yes

DRB1*0409

Polar E

Polar Y

Yes S

3

Yes

DRB1*07

Hydrophobic W

Hydrophobic F

Yes V

1

No

DRB1*0801

Polar E

Polar Y

Yes S

3

Yes

DRB1*0901

Charged K

Polar N

Yes V

3

Yes

DRB1*1001

Polar E

Polar Y

No

2

No

DRB1*11

Polar E

Polar Y/N/S/D

No

2

Yes

DRB1*11

Polar E

Hydrophobic, F

No

1

No

DRB1*12

Polar E

Hydrophobic L/F

Yes V

2

No

DRB1*1301

Polar E

Polar N

No

2

Yes

DRB1*1303

Polar E

Polar Y

Yes S

3

Yes

DRB1*1401

Polar E

Hydrophobic F

Yes A

2

No

DRB1*1402

Polar E

Polar N

No

2

No

DRB1*15

Hydrophobic W

Polar S

No

1

No

DRB1*16

Hydrophobic W

Polar S

No

1

No

DRB3*0101

Polar E

Hydrophobic F

Yes V

2

No

DRB3*0200

Polar E

Polar Y

No

2

Yes

DRB5*0202

Polar Q

Polar D/N

No

2

Yes

DQB1*05

Polar Y

Polar Y

Yes V

3

Yes

DQB1*0201

Polar Y

Hydrophobic I

Yes A

2

Yes

DQB1*0301

Polar Y

Polar Y

No

2

Yes

DQB1*0302

Polar Y

Polar Y

Yes A

3

Yes

DQB1*0303

Polar Y

Polar Y

No

2

Yes

DQB1*0601

Hydrophobic L

Polar D

No

1

No

DQB1*0602

Hydrophobic F

Polar Y

No

1

No

DQB1*0603

Polar Y

Polar Y

No

2

No

DQB1*0604

Polar Y

Polar Y

Yes V

3

Yes

  1. Polymorphic residues within pocket P9 of class II MHC alleles are scored according to whether they are polar/charged (+1), hydrophobic (0) or whether the conserved β57 aspartic acid is replaced (+1). A replacement at β57 Asp leaves α76 Arg free to coordinate an acidic peptide anchor in P9, or when the pocket is hydrophobic move out of the pocket. Two polar residues in the pocket or a polar residue and β57 aspartic acid mutation distinguishes between alleles that predispose to diabetes and those that do not with few exceptions. Diabetes association in column 6 is culled from the published literature. DR11 is listed both as a susceptibility allele and as a resistant (neutral) allele. Typing was to two significant figures; this obscures the nature of residue at β37.