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Figure 3 | Biology Direct

Figure 3

From: A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes

Figure 3

Hydrogen bond interactions involving GAD65 P9 Glu in I-Ag7. Hydrogen bonding interactions between the peptide P9 glutamic acid and residues in mouse I-Ag7 are shown. There is notably no hydrogen bond between the peptide P9 Glu and β37 Tyr. There is instead an important hydrogen bond between peptide P9 Glu and β57 Ser. A hydrogen bond is also maintained between α76 Arg and β57 Ser. These interactions vary from the equivalent interactions between insulin B peptide P9 Glu in human DQ8.

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