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Table 2 Transcription factors with significant target overlap to WT1

From: In silico regulatory analysis for exploring human disease progression

TF

Hypergeometric p-value

# of genes overlapped

Selected KEGG Pathways of targets shared with Wt1

GLI1

0

36

MapK Signalling, Tight Junction, Focal Adhesion

MEF2A

0

29

MapK Signalling, Regulation of Actin Cytoskeleton

NFIC

0

16

MapK Signalling, Regulation of Actin Cytoskeleton, Insulin Signalling

E2F

2.0e-12

52

Calcium Signaling, Notch Signalling, Regulation of Actin Cytoskeleton, WNT Signalling

SRF

1.3e-10

11

MapK Signalling

POU5F1

6.2e-10

38

Neuroactive Ligand Receptor Interaction, MapK Signalling

YY1

3.8e-6

6

MapK Signalling, Regulation of Actin Cytoskeleton

SPI1

1.1e-3

4

--

NANOG

6.7e-3

23

MapK Signalling, Regulation of Actin Cytoskeleton

POU1F1

7.7e-3

1

-

CEBPB

1.1e-2

6

Neuroactive Ligand Receptor Interaction

GATA1

1.5e-2

3

MapK Signalling, Regulation of Actin Cytoskeleton

T3R

1.9e-2

2

MapK Signalling

  1. TFs that have been determined to have significant regulatory overlap to WT1 are given. The p-value for the significance of the overlap as calculated by hypergeometric test is given in column 2. Column 3 lists the number of genes regulated by WT1 and the TF listed in each row. Column 4 lists a selection of the most common pathways in which the targets fall.
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Biology Direct

ISSN: 1745-6150

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