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Table 8 Adherens junction genes in human spermatogenesis data.

From: On the necessity of different statistical treatment for Illumina BeadChip and Affymetrix GeneChip data and its significance for biological interpretation

  

σ μ

σ wtrep

 

Gene Symbol

RefSeq ID

log2FC

P-value

log2FC

P-value

Gene Description

ACTG1

NM_001614

-0.81

0.064

-1.14

0.000

actin, gamma 1

BAIAP2

NM_006340

1.32

0.016

1.27

0.000

BAI1-associated protein 2

CREBBP

NM_004380

-0.98

0.002

-1.11

0.000

CREB binding protein (Rubinstein-Taybi syndrome)

CSNK2A2

NM_001896

-1.00

0.014

-1.57

0.000

Casein kinase 2, alpha prime polypeptide

CTNNA1

NM_001903

-0.93

0.009

-1.04

0.000

catenin (cadherin-associated protein), alpha 1, 102 kDa

FER

NM_005246

-1.37

0.015

-1.73

0.000

fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)

IQGAP1

NM_003870

-2.66

0.026

-2.27

0.000

IQ motif containing GTPase activating protein 1

MAPK1

NM_002745

-1.56

0.014

-1.34

0.000

mitogen-activated protein kinase 1

MAPK3

NM_002746

1.75

0.042

1.88

0.000

mitogen-activated protein kinase 3

PTPRF

NM_130440

-0.91

0.000

-1.10

0.000

protein tyrosine phosphatase, receptor type, F

SMAD2

NM_005901

-1.27

0.027

-1.59

0.000

SMAD family member 2

TCF7

NM_003202

3.13

0.045

2.90

0.000

transcription factor 7 (T-cell specific, HMG-box)

TJP1

NM_175610

-2.63

0.038

-2.10

0.000

tight junction protein 1 (zona occludens 1)

WASL

NM_003941

-1.99

0.047

-1.42

0.000

Wiskott-Aldrich syndrome-like

ACP1

NM_004300

-1.82

0.009

-1.66

0.000

acid phosphatase 1, soluble

ACP1

NM_007099

-1.77

0.000

-1.70

0.000

acid phosphatase 1, soluble

CDC42

NM_044472

-1.67

0.001

-1.51

0.000

cell division cycle 42 (GTP binding protein, 25 kDa)

CSNK2B

NM_001320

-2.61

0.006

-2.69

0.000

casein kinase 2, beta polypeptide

CTNNA2

NM_004389

-1.64

0.002

-1.88

0.000

catenin (cadherin-associated protein), alpha 2

MAP3K7

NM_145333

-1.52

0.000

-1.39

0.000

mitogen-activated protein kinase kinase kinase 7

MAPK1

NM_138957

-1.19

0.005

-1.23

0.000

mitogen-activated protein kinase 1

MAPK1

NM_138957

-1.68

0.002

-2.03

0.000

mitogen-activated protein kinase 1

RHOA

NM_001664

-1.81

0.001

-1.58

0.000

ras homolog gene family, member A

SMAD4

NM_005359

-1.02

0.000

-1.07

0.000

SMAD family member 4

SORBS1

NM_015385

1.86

0.001

1.99

0.000

sorbin and SH3 domain containing 1

WASF3

NM_006646

-1.62

0.002

-1.80

0.000

WAS protein family, member 3

CTNNA3

NM_013266

-1.03

0.007

-0.92

0.000

catenin (cadherin-associated protein), alpha 3

  1. The first, second and last column indicate the gene symbol, the RefSeq ID and the description of each Tight junction gene respectively. The third and fourth columns indicate the logarithm fold change and the P-value of each gene found by using σ μ as the summary statistic. The fifth and sixth columns indicate the logarithm fold change and the P-value of each gene found by using σ wtrep as the summary statistic. Cutoff criteria of p ≤ 0.01 and |FC| ≥ 2 were applied. The first 14 genes are found to be statistically significant by σ wtrep only. The lower part of the table lists genes found by both statistics except for the last row that contains a gene excluded by σ wtrep due to |FC| ≤ 2 (although p ≤ 0.01).