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Table 6 N-glycan biosynthesis genes in human spermatogenesis data.

From: On the necessity of different statistical treatment for Illumina BeadChip and Affymetrix GeneChip data and its significance for biological interpretation

  

σ μ

σ wtrep

 

Gene Symbol

RefSeq ID

log2FC

p value

log2FC

p value

Gene Description

B4GALT1

NM_001497

-0.45

0.499

-1.08

0.000

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

DDOST

NM_005216

-2.22

0.067

-1.18

0.000

dolichyl-diphosphooligosaccharide-protein glycosyltransferase

DHDDS

NM_024887

3.60

0.049

3.62

0.000

dehydrodolichyl diphosphate synthase

DPM1

NM_003859

-0.65

0.320

-1.06

0.000

dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

GANAB

NM_198334

1.45

0.045

2.12

0.000

glucosidase, alpha; neutral AB

MAN1A2

NM_006699

-1.27

0.019

-1.28

0.000

mannosidase, alpha, class 1A, member 2

MAN2A2

NM_006122

-0.81

0.001

-1.06

0.000

mannosidase, alpha, class 2A, member 2

UGCGL2

NM_020121

-0.97

0.003

-1.25

0.000

UDP-glucose ceramide glucosyltransferase-like 2

ALG2

NM_033087

-2.18

0.000

-2.20

0.000

asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)

ALG5

NM_013338

-1.90

0.000

-1.71

0.000

asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase)

ALG8

NM_024079

-1.36

0.001

-1.52

0.000

asparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)

B4GALT2

NM_003780

2.33

0.006

2.29

0.000

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2

MAN2A1

NM_002372

-1.21

0.055

-1.33

0.000

mannosidase, alpha, class 2A, member 1

MGAT4A

NM_012214

-1.84

0.001

-1.72

0.000

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

OGT

NM_181673

-2.31

0.009

-2.12

0.000

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

RPN1

NM_002950

-1.46

0.001

-1.51

0.000

ribophorin I

RPN2

NM_002951

-1.95

0.000

-2.00

0.000

ribophorin II

  1. The first, second and last column indicate the gene symbol, the RefSeq ID and the description of each N-glycan biosynthesis gene respectively. The third and fourth columns indicate the logarithm fold change and the P-value of each gene found by using σ μ as the summary statistic. The fifth and sixth columns indicate the logarithm fold change and the P-value of each gene found by using σ wtrep as the summary statistic. The cutoff criteria p ≤ 0.01 and |FC| ≥ 2 were applied. The first 8 genes are found to be statistically significant by σ wtrep only, the rest was found with both statistics.