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Figure 2 | Biology Direct

Figure 2

From: cpRAS: a novel circularly permuted RAS-like GTPase domain with a highly scattered phylogenetic distribution

Figure 2

(A) Phylogenetic distribution and presumed losses of the cpRAS domain in eukaryotes. Species containing the domain (in red) are shown in the context of the global eukaryotic phylogeny (based on recent phylogenetic literature). Dashed branches correspond to lineages that seem to have lost the cpRAS domain (genomes examined for the presence of but lacking the domain are listed in Table S1 in Additional file 1). The question mark indicates that it is unclear whether the absence of the cpRAS domain in Chromalveolata and Chloroplastida+Rhodophyta is primary or secondary. (B) Domain organisation of CPRas proteins. Blue zones indicate regions of mutual homology between CPRas proteins (here exemplified by Dictyostelium representatives) and related proteins lacking a cpRAS domain indicated by BLASTP. Only the C-terminal half of DdiCPRas2 is shown (the N-terminal half does not contain any recognisable conserved domain or motif). The domains with dashed outlines are recognised with insignificant E-values or are suggested on the basis of visual inspection of a multiple alignment only. For brevity, only a single representative of a larger family of paralogous VWA domain-containing proteins is indicated for each Tetrahymena and Paramecium.

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