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Table 1 Secondary structure features of major β-GF structural categories.

From: Small but versatile: the extraordinary functional and structural diversity of the β-grasp fold

Higher-order Classification

Lineage Name

Secondary Structural Features Common to the β-GF Fold1

  

S1

L1

S2

L2

H

L3/LS

S3

L4

S4

L5/CA

S5

tail

notes

Basal 4-stranded versions of the β-GF

IF3-N

S1

--

S2

--

H

--

S3

--

O

O

S5

--

 
 

Archeo-eukaryotic RNA poly. β-subunit

S1

--

S2

--

H

--

S3

--

O

O

S5

--

 

Sporadically-distributed 4-stranded versions

Yml108w

S1

cc

S2

--

H

--

S3

--

O

O

S5

h

 
 

BofC

S1

--

S2

--

H

--

S3

--

O

O

S5

--

 
 

Immunoglobulin-binding

S1

--

S2

--

H

--

S3

--

O

O

S5

--

 
 

POZ

S1

--

S2

--

H

h

S3

--

O

O

S5

--

 

Nudix superfamily

Nudix (MutT)

S1

--

S(ee)2

--

H

*

S3

--

O

O

S5

e

 

Fasciclin-like assemblage

L25

S1

--

S2

--

H

ee*

S3

--

O

O

S5

--

3

 

glutamine synthetase N-terminal

S1

--

S2

--

H

eee*

S3

--

O

O

S5

--

3

 

fasciclin

S1

hhh

S2

--

H

ee*

S3

--

O

O

S5

--

3

 

phosphoribosyl AMP cyclohydrolase (HisI)

S1

--

S2

--

H

ee*

S3

--

O

O

S5

--

3,4

5-stranded assemblage: classical 5-stranded clade

MoaD

S1

H

S2

--

H

h**

S3

--

S4

*

S5

--

 
 

ThiS

S1

--

S2

--

H

*

S3

--

S4

*

S5

--

 
 

TmoB

S1

--

S2

--

H

*

S3

--

S4

*

S5

--

 
 

Superantigen

S1

--

S2

--

H

*

S3

--

S4

h*

S5

--

 
 

Strepto/Staphylokinase

S1

--

S2

--

H

*

S3

--

S4

*

S5

--

 
 

YukD

S1

--

S2

--

H

*

S3

--

S4

*

S5

--

 
 

TGS

S1

--

S2

--

H

h*

S3

--

S4

*

S5

--

 
 

Aldehyde OR2 N-terminal domain

S1

--

S2

--

H

*

S3

--

S4

eh*

S5

--

 

5-stranded assemblage: Selected eukaryote UB-like superfamily members

classic UB-like

S1

--

S2

--

H

*

S3

--

S4

*

S5

--

 
 

PB1

S1

--

S2

--

H

*

S3

--

S4

h*

S5

--

 
 

CAD/Doublecortin (DCX)

S1

--

S2

--

H

*

S3

--

S4

[h]*

S5

--

6

 

RA

S1

--

S2

--

H

*

S3

--

S4

h*

S5

--

 
 

Elongin

S1

--

S2

--

H

*

S3

--

S4

*

S5

--

 
 

UBX

S1

--

S2

--

H

*

S3

--

S4

*

S5

--

 
 

E1/UFD

O

--

S2

--

H

*

S3

--

S4

*

S5

S6

7

5-stranded assemblage: soluble ligand binding or metal ion chelating clade

molydopterin-dependent oxidoreductase

S1

--

S2

hehee

H

*

S3

--

S4

eee*

S5

--

 
 

SLBB: Nqo1-type

S1

--

S2

--

H

*

S3

--

S4

hh*

S5

--

5

 

SLBB: transcobalamin-type

S1

--

S2

--

H

eee*

S3

--

S4

*

S5

--

 
 

2Fe-2S ferredoxin

S1

--

S2

--

H

cc*

S3

--

S4

*

S5

--

 
 

L-proline DH-like OR2 N-terminal domain

S1

--

S2

--

H

ee*

S3

--

S4

*

S5

--

 

Miscellaneous

WWE

S1

--

S2

--

H

e*

S3

--

O

O

S5

e

8

 

FimD N-terminal

S1

--

S2

ee

H

*

S3

--

O

O

S5

--

 
 

S4

O

O

O

O

H

h*

S3

--

S4

*

S5

--

 
  1. 1. S: Strand, L: Loop, H: Helix, LS: Lateral Shelf, CA: Connector Arm, O: absence of given feature, --: presence of a loop feature, *: presence of LS or CA, h: insert in helical conformation, e: insert in extended conformation (strand-like), cc: long coil insert.
  2. 2. OR: oxidoreductase.
  3. 3. Versions form barrel through insertion of strands at the lateral shelf.
  4. 4. Barrel is less pronounced in this version, strands are inserted more upstream relative to the other 3 versions.
  5. 5. Two small helices are present in ascending arm.
  6. 6. Single helix found at ascending arm in several members.
  7. 7. Circular permutation results in new connections between strands; the S1 strand is found at C-terminus (See Figures 1, 2).
  8. 8. Additional strand at tail inserted between S1 and S5; lateral shelf forms strand that also stacks with central sheet.