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Table 1 Principal component analysis of activity profiles.

From: Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution

  12-pNCA 2PE PROP 11PA 2A5C MDOB
PC1 (explains 62% of variance) 0.25 0.61 0.05 0.29 0.47 0.51
PC2 (explains 20% of variance) -0.48 -0.39 0.14 -0.27 0.70 0.19
  1. The first two principal components explain 82% of the variance in P450 activity profiles. The table shows the composition of these two components and the variance explained by each. The first component contains positive contributions from all substrates and can be thought of as representing a general high catalytic ability. The second component can be thought of as representing discrimination between fused ring substrates (PROP, 2A5C, and MDOB) and phenolic ether substrates (12-pNCA, 11PA, 2PE). Substrate abbreviations are as defined in the legend to Figure 2. The analysis was performed on the logarithms of the fold changes in activity.