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Table 3 The NSMC and NSCS test results for BRCA1, BRCA2, and p16 genes

From: Mutational hotspots in the TP53gene and, possibly, other tumor suppressors evolve by positive selection

Class ID

Sites

Mutations

Hotspots

P(H1)/χ2

BRCA1

Synonymous

33

142

16

 

Non-synonymous

356

1842

170

0.204/0.006

Nonsense

141

704

74

0.079

BRCA2

Synonymous

55

103

20

 

Non-synonymous

797

4871

352

0.071/1.2

Nonsense

179

844

79

0.018

p16

Synonymous

40

63

13

 

Non-synonymous

171

321

65

0.388/0.423

Nonsense

18

162

14

0.070

  1. The data for combined spectra from all tumor types are shown. Other designations are as in Table 1.
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Biology Direct

ISSN: 1745-6150

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