Mutational hotspots in the TP53gene and, possibly, other tumor suppressors evolve by positive selection

Biology Direct

Table 2 Combined NSMC and NSCS test results for the TP53 somatic mutations spectra

Class ID	Sites	Mutations	Hotspots	P(H1)/χ²
Class I^a
Synonymous	157	390	76
Non-synonymous	527	5710	385	*0.990/33.4*
Nonsense	78	529	59	0.023
Class II ^b
Synonymous	172	391	97
Non-synonymous	495	6109	379	*0.991/25.4*
Nonsense	72	629	55	0.018
Class III ^c
Synonymous	217	781	151
Non-synonymous	617	11819	474	*0.994/4.47*
Nonsense	88	1158	76	0.011

^a Class I: combined mutational spectrum of the tumor types for which H0 is rejected in comparison of synonymous vs. non-synonymous substitutions:brain, liver, lung, colon, mouth, larynx, ovary and skin.
^b Class II: combined mutational spectrum of the tumor types for which the test did not find enough evidence, probably, because of the small sample size: bladder, breast, prostate, esophagus, colorectal, hematopoietic, stomach, and pancreas.
^c Class III: combined Class I and Class II spectra.
Other designations are as in Table 1.

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