Figure 1

Evolutionary conservation of the SecY channel. Structure of the Methanococcus jannaschii SecY protein with sequence conservation mapped onto it. Conservation scores for SecY were calculated using the ConSurf server [22-24] based on a multiple alignment of 23 archaebacterial, 25 eukaryotic and 24 eubacterial SecY sequences. The conservation scores were displayed on the structure of SecY from Methanococcus jannaschii [15] (PDB code 1RH5) using Pymol [25] and the color_b.py script [26]. A) and B) are lateral views from the plane of the membrane, C) and D) are cytoplasmic views. B) and D) are sectioned at the middle of the molecule.