TY - JOUR AU - Kitano, H. PY - 2003 DA - 2003// TI - Cancer robustness: tumour tactics JO - Nature VL - 426 UR - https://doi.org/10.1038/426125a DO - 10.1038/426125a ID - Kitano2003 ER - TY - JOUR AU - Kitano, H. PY - 2004 DA - 2004// TI - Cancer as a robust system: implications for anticancer therapy JO - Nat Rev Cancer VL - 4 UR - https://doi.org/10.1038/nrc1300 DO - 10.1038/nrc1300 ID - Kitano2004 ER - TY - JOUR AU - Alexandrova, R. PY - 2001 DA - 2001// TI - Tumour heterogeneity JO - Exper Path and Paras VL - 4 ID - Alexandrova2001 ER - TY - JOUR AU - Gonzalez-Garcia, I. AU - Sole, R. V. AU - Costa, J. PY - 2002 DA - 2002// TI - Metapopulation dynamics and spatial heterogeneity in cancer JO - Proc Natl Acad Sci U S A VL - 99 UR - https://doi.org/10.1073/pnas.202139299 DO - 10.1073/pnas.202139299 ID - Gonzalez-Garcia2002 ER - TY - JOUR AU - Maley, C. C. AU - Galipeau, P. C. AU - Finley, J. C. AU - Wongsurawat, V. J. AU - Li, X. AU - Sanchez, C. A. AU - Paulson, T. G. AU - Blount, P. L. AU - Risques, R. A. AU - Rabinovitch, P. S. AU - Reid, B. J. PY - 2006 DA - 2006// TI - Genetic clonal diversity predicts progression to esophageal adenocarcinoma JO - Nat Genet VL - 38 UR - https://doi.org/10.1038/ng1768 DO - 10.1038/ng1768 ID - Maley2006 ER - TY - JOUR AU - Maley, C. C. AU - Reid, B. J. PY - 2005 DA - 2005// TI - Natural selection in neoplastic progression of Barrett's esophagus JO - Semin Cancer Biol VL - 15 UR - https://doi.org/10.1016/j.semcancer.2005.06.004 DO - 10.1016/j.semcancer.2005.06.004 ID - Maley2005 ER - TY - JOUR AU - Heppner, G. H. PY - 1984 DA - 1984// TI - Tumor heterogeneity JO - Cancer Res VL - 44 ID - Heppner1984 ER - TY - JOUR AU - Heppner, G. H. AU - Miller, F. R. PY - 1998 DA - 1998// TI - The cellular basis of tumor progression JO - Int Rev Cytol VL - 177 UR - https://doi.org/10.1016/S0074-7696(08)62230-5 DO - 10.1016/S0074-7696(08)62230-5 ID - Heppner1998 ER - TY - JOUR AU - Harris, J. F. AU - Chambers, A. F. AU - Ling, V. AU - Hill, R. P. PY - 1987 DA - 1987// TI - Dynamic heterogeneity: characterization of two cell lines derived from experimental lung metastases of mouse KHT fibrosarcoma JO - Invasion Metastasis VL - 7 ID - Harris1987 ER - TY - JOUR AU - Hill, R. P. AU - Chambers, A. F. AU - Ling, V. AU - Harris, J. F. PY - 1984 DA - 1984// TI - Dynamic heterogeneity: rapid generation of metastatic variants in mouse B16 melanoma cells JO - Science VL - 224 UR - https://doi.org/10.1126/science.6719130 DO - 10.1126/science.6719130 ID - Hill1984 ER - TY - JOUR AU - Nowell, P. C. PY - 1986 DA - 1986// TI - Mechanisms of tumor progression JO - Cancer Res VL - 46 ID - Nowell1986 ER - TY - JOUR AU - Gorunova, L. AU - Dawiskiba, S. AU - Andren-Sandberg, A. AU - Hoglund, M. AU - Johansson, B. PY - 2001 DA - 2001// TI - Extensive cytogenetic heterogeneity in a benign retroperitoneal schwannoma JO - Cancer Genet Cytogenet VL - 127 UR - https://doi.org/10.1016/S0165-4608(00)00440-4 DO - 10.1016/S0165-4608(00)00440-4 ID - Gorunova2001 ER - TY - JOUR AU - Fujii, H. AU - Yoshida, M. AU - Gong, Z. X. AU - Matsumoto, T. AU - Hamano, Y. AU - Fukunaga, M. AU - Hruban, R. H. AU - Gabrielson, E. AU - Shirai, T. PY - 2000 DA - 2000// TI - Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity JO - Cancer Res VL - 60 ID - Fujii2000 ER - TY - JOUR AU - Goldie, J. H. AU - Coldman, A. J. PY - 1979 DA - 1979// TI - A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate JO - Cancer Treat Rep VL - 63 ID - Goldie1979 ER - TY - JOUR AU - Skipper, H. E. AU - Schabel, F. M. J. PY - 1984 DA - 1984// TI - Tumor stem cell heterogeneity: implications with respect to classification of cancers by chemotherapeutic effect JO - Cancer Treat Rep VL - 68 ID - Skipper1984 ER - TY - JOUR AU - Moolgavkar, S. H. AU - Knudson, A. G. J. PY - 1981 DA - 1981// TI - Mutation and cancer: a model for human carcinogenesis JO - J Natl Cancer Inst VL - 66 ID - Moolgavkar1981 ER - TY - JOUR AU - Michor, F. AU - Iwasa, Y. AU - Nowak, M. A. PY - 2004 DA - 2004// TI - Dynamics of cancer progression JO - Nat Rev Cancer VL - 4 UR - https://doi.org/10.1038/nrc1295 DO - 10.1038/nrc1295 ID - Michor2004 ER - TY - CHAP AU - Preziosi, L. PY - 2003 DA - 2003// BT - Cancer Modeling and Simulation PB - Boca Raton CY - FL , CRC UR - https://doi.org/10.1201/9780203494899 DO - 10.1201/9780203494899 ID - Preziosi2003 ER - TY - JOUR AU - Gatenby, R. A. PY - 1995 DA - 1995// TI - Models of Tumor-Host Interaction as Competing Populations: Implications for Tumor Biology and Treatment JO - Journal of Theoretical Biology VL - 176 UR - https://doi.org/10.1006/jtbi.1995.0212 DO - 10.1006/jtbi.1995.0212 ID - Gatenby1995 ER - TY - JOUR AU - Gatenby, R. A. AU - Vincent, T. L. PY - 2003 DA - 2003// TI - An evolutionary model of carcinogenesis JO - Cancer Res VL - 63 ID - Gatenby2003 ER - TY - JOUR AU - Gatenby, R. A. AU - Vincent, T. L. PY - 2003 DA - 2003// TI - Application of quantitative models from population biology and evolutionary game theory to tumor therapeutic strategies JO - Mol Cancer Ther VL - 2 ID - Gatenby2003 ER - TY - CHAP AU - Wodarz, D. AU - Komarova, N. PY - 2005 DA - 2005// BT - Computational biology of cancer UR - https://doi.org/10.1142/5642 DO - 10.1142/5642 ID - Wodarz2005 ER - TY - JOUR AU - Komarova, N. L. PY - 2005 DA - 2005// TI - Mathematical modeling of tumorigenesis: mission possible JO - Curr Opin Oncol VL - 17 UR - https://doi.org/10.1097/01.cco.0000143681.37692.32 DO - 10.1097/01.cco.0000143681.37692.32 ID - Komarova2005 ER - TY - CHAP AU - Goldie, J. H. AU - Coldman, A. J. PY - 1998 DA - 1998// BT - Drug Resistance in Cancer: Mechanisms and Models UR - https://doi.org/10.1017/CBO9780511666544 DO - 10.1017/CBO9780511666544 ID - Goldie1998 ER - TY - CHAP AU - Martin, R. AU - Teo, K. L. PY - 1993 DA - 1993// BT - Optimal control of drug administration in cancer chemotherapy ID - Martin1993 ER - TY - JOUR AU - de Pillis, L. G. AU - Gu, W. AU - Radunskaya, A. E. PY - 2006 DA - 2006// TI - Mixed immunotherapy and chemotherapy of tumors: modeling, applications and biological interpretations JO - Journal of Theoretical Biology VL - 238 UR - https://doi.org/10.1016/j.jtbi.2005.06.037 DO - 10.1016/j.jtbi.2005.06.037 ID - de Pillis2006 ER - TY - JOUR AU - Liu, W. AU - Freedman, H. I. PY - 2005 DA - 2005// TI - A mathematical model of vascular tumor treatment by chemotherapy JO - Mathematical and Computer Modelling VL - 42 UR - https://doi.org/10.1016/j.mcm.2004.09.008 DO - 10.1016/j.mcm.2004.09.008 ID - Liu2005 ER - TY - JOUR AU - Birkhead, B. G. AU - Rankin, E. M. AU - Gallivan, S. AU - Dones, L. AU - Rubens, R. D. PY - 1987 DA - 1987// TI - A mathematical model of the development of drug resistant to cancer chemotherapy JO - European Journal of Cancer and Clinical Oncology VL - 23 UR - https://doi.org/10.1016/0277-5379(87)90133-7 DO - 10.1016/0277-5379(87)90133-7 ID - Birkhead1987 ER - TY - JOUR AU - Lakmeche, A. AU - Arino, O. PY - 2001 DA - 2001// TI - Nonlinear mathematical model of pulsed-therapy of heterogeneous tumors JO - Nonlinear Analysis: Real World Applications VL - 2 UR - https://doi.org/10.1016/S1468-1218(01)00003-7 DO - 10.1016/S1468-1218(01)00003-7 ID - Lakmeche2001 ER - TY - STD TI - Norris ES, King JR, Byrne HM: Modelling the response of spatially structured tumours to chemotherapy: Drug kinetics.Mathematical and Computer ModellingIn Press, Corrected Proof: ID - ref30 ER - TY - JOUR AU - Stephanou, A. AU - McDougall, S. R. AU - Anderson, A. R. A. AU - Chaplain, M. A. J. PY - 2005 DA - 2005// TI - Mathematical modelling of flow in 2D and 3D vascular networks: Applications to anti-angiogenic and chemotherapeutic drug strategies JO - Mathematical and Computer Modelling VL - 41 UR - https://doi.org/10.1016/j.mcm.2005.05.008 DO - 10.1016/j.mcm.2005.05.008 ID - Stephanou2005 ER - TY - JOUR AU - Chaplain, M. A. J. PY - 1996 DA - 1996// TI - Avascular growth, angiogenesis and vascular growth in solid tumours: The mathematical modelling of the stages of tumour development JO - Mathematical and Computer Modelling VL - 23 UR - https://doi.org/10.1016/0895-7177(96)00019-2 DO - 10.1016/0895-7177(96)00019-2 ID - Chaplain1996 ER - TY - JOUR AU - Lankelma, J. AU - Fernandez Luque, R. AU - Dekker, H. AU - Pinedo, H. M. PY - 2003 DA - 2003// TI - Simulation model of doxorubicin activity in islets of human breast cancer cells JO - Biochim Biophys Acta VL - 1622 UR - https://doi.org/10.1016/S0304-4165(03)00139-9 DO - 10.1016/S0304-4165(03)00139-9 ID - Lankelma2003 ER - TY - JOUR AU - Drasdo, D. AU - Hohme, S. PY - 2003 DA - 2003// TI - Individual-based approaches to birth and death in avascu1ar tumors JO - Mathematical and Computer Modelling VL - 37 UR - https://doi.org/10.1016/S0895-7177(03)00128-6 DO - 10.1016/S0895-7177(03)00128-6 ID - Drasdo2003 ER - TY - JOUR AU - Quaranta, V. AU - Weaver, A. M. AU - Cummings, P. T. AU - Anderson, A. R. A. PY - 2005 DA - 2005// TI - Mathematical modeling of cancer: The future of prognosis and treatment JO - Clinica Chimica Acta VL - 357 UR - https://doi.org/10.1016/j.cccn.2005.03.023 DO - 10.1016/j.cccn.2005.03.023 ID - Quaranta2005 ER - TY - JOUR AU - Kirn, D. H. AU - McCormick, F. PY - 1996 DA - 1996// TI - Replicating viruses as selective cancer therapeutics JO - Mol Med Today VL - 2 UR - https://doi.org/10.1016/S1357-4310(97)81456-6 DO - 10.1016/S1357-4310(97)81456-6 ID - Kirn1996 ER - TY - JOUR AU - Parato, K. A. AU - Senger, D. AU - Forsyth, P. A. AU - Bell, J. C. PY - 2005 DA - 2005// TI - Recent progress in the battle between oncolytic viruses and tumours JO - Nat Rev Cancer VL - 5 UR - https://doi.org/10.1038/nrc1750 DO - 10.1038/nrc1750 ID - Parato2005 ER - TY - JOUR AU - McCormick, F. PY - 2003 DA - 2003// TI - Cancer-specific viruses and the development of ONYX-015 JO - Cancer Biol Ther VL - 2 ID - McCormick2003 ER - TY - JOUR AU - Kasuya, H. AU - Takeda, S. AU - Nomoto, S. AU - Nakao, A. PY - 2005 DA - 2005// TI - The potential of oncolytic virus therapy for pancreatic cancer JO - Cancer Gene Ther VL - 12 UR - https://doi.org/10.1038/sj.cgt.7700830 DO - 10.1038/sj.cgt.7700830 ID - Kasuya2005 ER - TY - JOUR AU - Kaplan, J. M. PY - 2005 DA - 2005// TI - Adenovirus-based cancer gene therapy JO - Curr Gene Ther VL - 5 UR - https://doi.org/10.2174/156652305774964677 DO - 10.2174/156652305774964677 ID - Kaplan2005 ER - TY - JOUR AU - Kirn, D. AU - Hermiston, T. AU - McCormick, F. PY - 1998 DA - 1998// TI - ONYX-015: clinical data are encouraging JO - Nat Med VL - 4 UR - https://doi.org/10.1038/3902 DO - 10.1038/3902 ID - Kirn1998 ER - TY - JOUR AU - Khuri, F. R. AU - Nemunaitis, J. AU - Ganly, I. AU - Arseneau, J. AU - Tannock, I. F. AU - Romel, L. AU - Gore, M. AU - Ironside, J. AU - MacDougall, R. H. AU - Heise, C. AU - Randlev, B. AU - Gillenwater, A. M. AU - Bruso, P. AU - Kaye, S. B. AU - Hong, W. K. AU - Kirn, D. H. PY - 2000 DA - 2000// TI - a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer JO - Nat Med VL - 6 UR - https://doi.org/10.1038/78638 DO - 10.1038/78638 ID - Khuri2000 ER - TY - JOUR AU - Nemunaitis, J. AU - Khuri, F. AU - Ganly, I. AU - Arseneau, J. AU - Posner, M. AU - Vokes, E. AU - Kuhn, J. AU - McCarty, T. AU - Landers, S. AU - Blackburn, A. AU - Romel, L. AU - Randlev, B. AU - Kaye, S. AU - Kirn, D. PY - 2001 DA - 2001// TI - Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer JO - J Clin Oncol VL - 19 ID - Nemunaitis2001 ER - TY - JOUR AU - Shah, A. C. AU - Benos, D. AU - Gillespie, G. Y. AU - Markert, J. M. PY - 2003 DA - 2003// TI - Oncolytic viruses: clinical applications as vectors for the treatment of malignant gliomas JO - J Neurooncol VL - 65 UR - https://doi.org/10.1023/B:NEON.0000003651.97832.6c DO - 10.1023/B:NEON.0000003651.97832.6c ID - Shah2003 ER - TY - JOUR AU - Kaufman, H. L. AU - Deraffele, G. AU - Mitcham, J. AU - Moroziewicz, D. AU - Cohen, S. M. AU - Hurst-Wicker, K. S. AU - Cheung, K. AU - Lee, D. S. AU - Divito, J. AU - Voulo, M. AU - Donovan, J. AU - Dolan, K. AU - Manson, K. AU - Panicali, D. AU - Wang, E. AU - Horig, H. AU - Marincola, F. M. PY - 2005 DA - 2005// TI - Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma JO - J Clin Invest VL - 115 UR - https://doi.org/10.1172/JCI24624 DO - 10.1172/JCI24624 ID - Kaufman2005 ER - TY - JOUR AU - Reid, T. AU - Warren, R. AU - Kirn, D. PY - 2002 DA - 2002// TI - Intravascular adenoviral agents in cancer patients: lessons from clinical trials JO - Cancer Gene Ther VL - 9 UR - https://doi.org/10.1038/sj.cgt.7700539 DO - 10.1038/sj.cgt.7700539 ID - Reid2002 ER - TY - CHAP AU - Shen, Y. AU - Nemunaitis, J. PY - 2006 DA - 2006// TI - Herpes simplex virus 1 (HSV-1) for cancer treatment BT - Cancer Gene Ther ID - Shen2006 ER - TY - JOUR AU - Thorne, S. H. AU - Negrin, R. S. AU - Contag, C. H. PY - 2006 DA - 2006// TI - Synergistic antitumor effects of immune cell-viral biotherapy JO - Science VL - 311 UR - https://doi.org/10.1126/science.1121411 DO - 10.1126/science.1121411 ID - Thorne2006 ER - TY - JOUR AU - Harrison, D. AU - Sauthoff, H. AU - Heitner, S. AU - Jagirdar, J. AU - Rom, W. N. AU - Hay, J. G. PY - 2001 DA - 2001// TI - Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved--deletion of the viral E1b-19-kD gene increases the viral oncolytic effect JO - Hum Gene Ther VL - 12 UR - https://doi.org/10.1089/104303401750270977 DO - 10.1089/104303401750270977 ID - Harrison2001 ER - TY - JOUR AU - Lorence, R. M. AU - Pecora, A. L. AU - Major, P. P. AU - Hotte, S. J. AU - Laurie, S. A. AU - Roberts, M. S. AU - Groene, W. S. AU - Bamat, M. K. PY - 2003 DA - 2003// TI - Overview of phase I studies of intravenous administration of PV701, an oncolytic virus JO - Curr Opin Mol Ther VL - 5 ID - Lorence2003 ER - TY - CHAP AU - Novozhilov, A. S. AU - Berezovskaya, F. S. AU - Koonin, E. V. AU - Karev, G. P. PY - 2006 DA - 2006// TI - Mathematical modeling of tumor therapy with oncolytic viruses: Regimes with complete tumor elimination within the framework of deterministic models BT - Biology Direct ID - Novozhilov2006 ER - TY - JOUR AU - Wodarz, D. PY - 2001 DA - 2001// TI - Viruses as antitumor weapons: defining conditions for tumor remission JO - Cancer Res VL - 61 ID - Wodarz2001 ER - TY - CHAP AU - Nowak, M. A. AU - May, R. M. PY - 2000 DA - 2000// BT - Virus Dynamics: mathematical principles of immunology and virology PB - New-York CY - Oxford ID - Nowak2000 ER - TY - JOUR AU - Tao, Y. AU - Guo, Q. PY - 2005 DA - 2005// TI - The competitive dynamics between tumor cells, a replication-competent virus and an immune response JO - J Math Biol VL - 51 UR - https://doi.org/10.1007/s00285-004-0310-6 DO - 10.1007/s00285-004-0310-6 ID - Tao2005 ER - TY - JOUR AU - Dyson, J. AU - Villella-Bressan, R. AU - Webb, G. F. PY - 2002 DA - 2002// TI - Asynchronous exponential growth in an age structured population of proliferating and quiescent cells JO - Mathematical Biosciences VL - 177-178 UR - https://doi.org/10.1016/S0025-5564(01)00097-9 DO - 10.1016/S0025-5564(01)00097-9 ID - Dyson2002 ER - TY - JOUR AU - Dushoff, J. PY - 1999 DA - 1999// TI - Host Heterogeneity and Disease Endemicity: A Moment-Based Approach JO - Theoretical Population Biology VL - 56 UR - https://doi.org/10.1006/tpbi.1999.1428 DO - 10.1006/tpbi.1999.1428 ID - Dushoff1999 ER - TY - CHAP AU - Hsu Schmitz, S. F. ED - Castillo-Chavez, C. ED - Blower, S. ED - Driessche, P. ED - Kirschner, D. ED - Yakubu, A. A. PY - 2002 DA - 2002// TI - Effects of genetic heterogeneity on HIV transmission in homosexual populations BT - Mathematical Approaches for Emerging and Reemerging Infectious Diseases: Models, Methods and Theory UR - https://doi.org/10.1007/978-1-4613-0065-6_14 DO - 10.1007/978-1-4613-0065-6_14 ID - Hsu Schmitz2002 ER - TY - JOUR AU - Dushoff, J. AU - Levin, S. PY - 1995 DA - 1995// TI - The effects of population heterogeneity on disease invasion JO - Mathematical Biosciences VL - 128 UR - https://doi.org/10.1016/0025-5564(94)00065-8 DO - 10.1016/0025-5564(94)00065-8 ID - Dushoff1995 ER - TY - JOUR AU - Ackleh, A. S. PY - 1998 DA - 1998// TI - Estimation of rate distributions in generalized Kolmogorov community models JO - Nonlinear Analysis VL - 33 UR - https://doi.org/10.1016/S0362-546X(97)00665-2 DO - 10.1016/S0362-546X(97)00665-2 ID - Ackleh1998 ER - TY - CHAP AU - Diekmann, O. AU - Heesterbeek, H. AU - Metz, H. ED - Mollison, D. PY - 1995 DA - 1995// TI - The Legacy of Kermack and McKendrick BT - Epidemic Models: Their Structure and Relation to Data ID - Diekmann1995 ER - TY - JOUR AU - Karev, G. PY - 2000 DA - 2000// TI - The effects of non-homogeneity in population dynamics JO - Doklady Matematica VL - 62 ID - Karev2000 ER - TY - JOUR AU - Karev, G. PY - 2005 DA - 2005// TI - Dynamics of heterogeneous populations and communities and evolution of distributions JO - Dis and Cont Dyn Sys VL - Suppl ID - Karev2005 ER - TY - JOUR AU - Veliov, V. M. PY - 2003 DA - 2003// TI - Newton's method for problems of optimal control of heterogeneous systems JO - Optimization Methods & Software VL - 18 UR - https://doi.org/10.1080/10556780310001639753 DO - 10.1080/10556780310001639753 ID - Veliov2003 ER - TY - JOUR AU - Ackleh, A. S. AU - Marshall, D. F. AU - Heatherly, H. E. AU - Fitzpatrick, B. G. PY - 1999 DA - 1999// TI - Survival of the fittest in a generalized logistic model JO - Mathematical Models & Methods in Applied Sciences VL - 9 UR - https://doi.org/10.1142/S0218202599000610 DO - 10.1142/S0218202599000610 ID - Ackleh1999 ER - TY - JOUR AU - Novozhilov, A. S. PY - 2004 DA - 2004// TI - Analysis of a generalized population predator-prey model with a parameter distributed normally over the individuals in the predator population JO - Journal of Computer and Systems Sciences International VL - 43 ID - Novozhilov2004 ER - TY - JOUR AU - Veliov, V. M. PY - 2005 DA - 2005// TI - On the effect of population heterogeneity on dynamics of epidemic diseases JO - J of Math Bio VL - 51 UR - https://doi.org/10.1007/s00285-004-0288-0 DO - 10.1007/s00285-004-0288-0 ID - Veliov2005 ER -