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Figure 2 | Biology Direct

Figure 2

From: The signaling helix: a common functional theme in diverse signaling proteins

Figure 2

Multiple alignment of representative examples of the S-helix. Representatives from a multiple alignment of the S-Helix domain, generated using the MUSCLE program [49] and corrected using PSI-BLAST [47] search results, are shown. The logo and the heptad notations are shown. The 80% consensus shown below the alignment was derived from an alignment of all the members using the following amino acid classes: consensus from the logo is also shown and colored using the following amino acid classes: hydrophobic (h: ACFILMVWY, yellow shading); aliphatic subset of the hydrophobic class (l; ILV, yellow shading); the aromatic subset of the hydrophobic class (a; FHWY, yellow shading); small (s: ACDGNPSTV, green); the tiny subclass of small (u; GAS, Green shading); polar (p: CDEHKNQRST, blue); the charged subclass of polar (c: DEHKR, pink); the positive subclass of charged (+: HKR, pink); the negative subclass of charged (-: DE, pink); alcohol (o: ST, Blue); and big (b: KFILMQRWYE, grey). A 'L', or 'T' show the completely conserved amino acid in that group. The limits of the domains are indicated by the residue positions, on each side. The domain architecture is shown to the right. The domain abbreviations are as in section 2 Materials and Methods and legend to Fig. 4. The mutations discussed in the paper are marked with boxes. The sequences are denoted by their gene name followed by the species abbreviation and GeneBank Identifier. The species abbreviations are: Ana: Nostoc sp.; Atum: Agrobacterium tumefaciens; Bant: Bacillus anthracis; Cele: Caenorhabditis elegans; Dmel: Drosophila melanogaster; Ecol: Escherichia coli; Hsap: Homo sapiens; Iloi: Idiomarina loihiensis; Lint: Leptospira interrogans; Mace: Methanosarcina acetivorans; Paer: Pseudomonas aeruginosa; Scer: Saccharomyces cerevisiae; Vvul: Vibrio vulnificus; Xaxo: Xanthomonas axonopodis; Ypes: Yersinia pestis

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