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Table 1 Frequency of codon insertions and/or deletions in antigen-specific antibody Fabs isolated from vaccinated donors

From: Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires

Specificity

Donor

Vaccinea

#Fabsb

Insertionsc

Deletionsc

PPS 23F

002

conjugate

3

0

0

 

008

conjugate

10

1

0

 

014

conjugate

3

0

0

 

018

PPS

3

1

0

 

023

PPS

3

0

0

 

025

PPS

6

0

0

 

027

PPS

4

1

0

PPS 6B

001

conjugate

1

0

0

 

002

conjugate

5

0

0

 

003

conjugate

11

9

0

 

010

conjugate

11

0

1

 

011

conjugate

20

0

0

 

023

PPS

9

1

1

PPS 14

011

conjugate

4

1

1

 

012

conjugate

23

0

0

 

023

PPS

9

0

4

PA

001

AVA

32

0

1

  1. aVaccine; PPS (23-valent pneumococcal polysaccharide vaccine), conjugate (pneumococcal polysaccharides conjugate to CRM197) or AVA (anthrax vaccine). bNumber of antigen-specific Fabs isolated from this donor. cNumber of Fabs isolated with codon insertions and/or deletions.