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Figure 2 | Biology Direct

Figure 2

From: Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires

Figure 2

Effect of codon insertion and deletion on antigen binding. Fabs were mutated to either remove inserted codons, or replace deleted codons and the effect on relative affinity for PPS 6B measured. A) Relative affinity of Fab 6F2 for PPS 6B with (6F2) and without (6F2*) the 2 codon insertion into H chain CDR2 (see Table 4). B) Relative affinity of Fab 3H11 for PPS 6B with a 6 codon deletion in L chain CDR1(3H11; Table 3) compared to that of the Fab with the deleted residues restored to their germline sequence (3H11*).

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