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Table 1 Overrepresented GO terms from genes with TE-derived HS sites

From: Transposable element derived DNaseI-hypersensitive sites in the human genome

Clusters 1

GO id 2

GO level 3

GO name 4

Counts 5

P-values6

Immune response group

2

GO:0009607

4

response to biotic stimulus

21

4.9 × 10-7

25

   

8

1.7 × 10-2

2

GO:0006952

5

defense response

20

1.0 × 10-6

25

   

8

1.6 × 10-2

2

GO:0006955

6

immune response

20

3.6 × 10-7

25

   

8

1.3 × 10-2

2

GO:0051707

5

response to other organism

11

1.8 × 10-4

25

   

5

3.3 × 10-2

2

GO:0009613

6

response to pest, pathogen or parasite

11

1.0 × 10-4

25

   

5

2.7 × 10-2

2

GO:0030098

9

lymphocyte differentiation

3

6.2 × 10-3

19

   

3

1.6 × 10-2

Regulation group

15

GO:0050789

2

regulation of biological process

40

4.4 × 10-8

25

   

17

7.5 × 10-3

15

GO:0050794

3

regulation of cellular process

39

2.2 × 10-8

25

   

17

4.1 × 10-3

15

GO:0050791

3

regulation of physiological process

38

2.2 × 10-8

25

   

15

1.3 × 10-6

15

GO:0051244

4

regulation of cellular physiological process

38

1.3 × 10-8

25

   

15

1.3 × 10-2

Metabolism group

15

GO:0050875

3

cellular physiological process

73

6.5 × 10-4

19

   

88

3.8 × 10-3

15

GO:0044238

4

primary metabolism

63

1.7 × 10-6

19

   

67

4.8 × 10-3

15

GO:0044237

4

cellular metabolism

63

9.0 × 10-6

19

   

71

1.3 × 10-3

9

GO:0043170

4

macromolecule metabolism

26

2.8 × 10-2

15

   

37

2.0 × 10-2

19

   

50

9.1 × 10-4

9

GO:0043283

5

biopolymer metabolism

18

2.8 × 10-2

15

   

30

8.0 × 10-5

19

   

35

5.1 × 10-4

Cell death group

2

GO:0043067

6

regulation of programmed cell death

7

7.8 × 10-3

19

   

7

3.7 × 10-2

2

GO:0042981

7

regulation of apoptosis

7

7.8 × 10-3

19

   

7

3.7 × 10-2

  1. 1Gene coexpression, based on k-means analysis, cluster identifier.
  2. 2Biological process Gene Ontology (GO) annotation term.
  3. 3Hierarchical level (descending from 1) in the biological process GO directed acyclic graph.
  4. 4Name assigned to the GO term
  5. 5Number of genes in each cluster associated with the GO term.
  6. 6P-value associated with the over-representation of the GO term in each cluster