Figure 5From: Distinguishing HIV-1 drug resistance, accessory, and viral fitness mutations using conditional selection pressure analysis of treated versus untreated patient samplesEffects of mixing Treated and Untreated data on selection pressure calculation. We have mixed the Treated (1797 samples) with the Untreated (2628 samples) to assess the effects of a mixed data on selection pressure analysis. This mixing caused up to two-fold decreases in positively selected Ka/Ks values (compared with the Treated dataset), with shifts averaging of 32.7%. Out of the 24 positively selected codons in the Treated dataset, only two became negatively selected in the Mixture dataset. K a /K s values with a LOD < 2 in the Mixture dataset were plotted as empty triangles.Back to article page