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Fig. 6 | Biology Direct

Fig. 6

From: Biomimetic peroxidase MOF-Fe promotes bone defect repair by inhibiting TfR2 and activating the BMP2 pathway

Fig. 6

Therapeutic Efficacy of MOF-Fe Nanoparticles in Rat Femoral Bone Defect Restoration. (A) Micro-CT imaging: Three-dimensional reconstructions vividly demonstrate the facilitative impact of MOF-Fe nanoparticles on bone tissue regeneration. (B) Haematoxylin-eosin (H&E) and Masson’s trichrome staining showing neo-bone tissue morphology and bone collagen maturation status. Notably, in the MOF-0.125 and MOF-0.25 groups, the neo-bone structure exhibited a pronounced thickening compared to that of the control. (C) Trabecular bone volume (Tb.BV). (D) Trabecular tissue volume (Tb.TV). (E) Trabecular bone volume-to-tissue volume ratio (Tb.BV/TV). (F) Trabecular thickness (Tb.Th). (G) Trabecular bone mineral density (Tb.BMD). (H) Trabecular number (Tb.N). The data are presented as the means ± SDs (n = 3). *p < 0.05, **p < 0.01

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