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Table 2 The variables in univariate analysis and multivariate analysis of survival and their P values for acute myeloid leukemia

From: Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy

Variables

Univariate analysis

HR (CI 95%)

P value

Multivariate analysis

HR (CI 95%)

P value

AGE

1.032 (0.999–1.066)

0.057

  

SEX

0.840 (0.324–2.178)

0.720

  

WBC

1.001 (0.995–1.006)

0.821

  

Hb

1.000 (0.982–1.018)

0.991

  

PLT

1.001 (0.998–1.003)

0.671

  

BRAF expression

1.042 (1.015–1.069)

0.002

1.027 (0.991–1.064)

0.140

AGE ≥ 48 years

0.599 (0.227–1.582)

0.301

  

WT1 mutated and wt

0.770 (0.272–2.174)

0.621

  

FLT3-ITD mutated and wt

2.078 (0.582–7.418)

0.260

1.176 (0.310–4.455)

0.812

NPM1 mutated and wt

0.589 (0.077–4.479)

0.609

  

DNMT3A mutated and wt

1.332 (0.302–5.882)

0.705

  

TET2 mutated and wt

0.045 (0.000–526.014)

0.517

  

C-KIT mutated and wt

0.556 (0.072–4.278)

0.573

  

FLT3-TKD mutated and wt

1.344 (0.176–10.238)

0.775

  

IDH1 mutated and wt

0.047 (0.000–9361.29)

0.624

  

SRSF mutated and wt

0.048 (0.00–55212.04)

0.669

  

ASXL1 mutated and wt

0.048 (0.00–162969.9)

0.692

  

NRAS mutated and wt

0.047 (0.000–5527.25)

0.607

  

IDH2 mutated and wt

0.047 (0.00–13658.72)

0.634

  

Risk category

0.488 (0.246–0.969)

0.041

0.818 (0.326–2.054)

0.669

Treatment regimen

0.294 (0.125–0.692)

0.005

0.404 (0.177–0.923)

0.032

  1. WBC White blood cell count, PLT Platelets count, HGB Hemoglobin content, HR Hazard ratio