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Fig. 7 | Biology Direct

Fig. 7

From: Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy

Fig. 7

VEM synergistic BOR in anti-AML through HIPPO signaling pathway in vivo. After the administration, the tumors were excised, weighed, and photographed (A). The tumor weight (B), tumor volume (C) and weight of mice (D) were recorded every two days during the experiment, n = 4; E, the expression of YAP1 and TAZ was detected by immunohistochemistry in vivo; F–O, Expressions of the BAX, BCL-2, CDK2, CDK4, NEDD8, CUL5 and genes in HIPPO signaling pathway (MST2, YAP1, TAZ) were detected by western blot, GAPDH was used as a loading control. *P < .05; **P < .01; ***P < .001; ****P < .001. Data was presented as mean ± SD of three independent experiments

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Biology Direct

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