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Fig. 6 | Biology Direct

Fig. 6

From: Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy

Fig. 6

MST2 inhibitor reversed the anti-AML effects of VEM combined BOR. A MST2 inhibitor reversed the arrested of cell cycle at G0/G1 phase in AML cells; B–C Expressions of cell cycle related protein genes (CDK2, CDK4, P21,) were detected in SKM-1 cells by western blot, GAPDH was used as a loading control; D–E Expressions of cell cycle related protein genes (CDK2, CDK4, P21,) were detected in MOLM-13 cells by western blot, β-actin was used as a loading control; F–H Expressions of the genes in HIPPO signalin pathway (MST2, YAP1, TAZ) and apoptosis-related protein genes (BCL-2, BAX) were detected in SKM-1 cells by western blot, GAPDH was used as a loading control; I–K Expressions of the NEDD8, CUL5 and genes in HIPPO signalin pathway (MST2, YAP1, TAZ) and apoptosis-related protein genes (BCL-2, BAX) were detected in MOLM-13 cells by western blot, β-actin was used as a loading control. (COT-Control, COM-Drugs Combine, I-MST2 Inhibitor, I + COM-MST2 Inhibitor + Drugs Combine, *P < .05; **P < .01; ***P < .001; ****P < .001. Data was presented as mean ± SD of three independent experiments)

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Biology Direct

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