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Fig. 5 | Biology Direct

Fig. 5

From: Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy

Fig. 5

VEM and BOR treatment could turn on HIPPO signaling pathway in AML cell lines. A KEGG pathway enrichment analyses of the network pharmacology of VEM and BOR against AML-MDS; B Gene set enrichment analysis of apoptosis comparing SKM-1 cells treated VEM and drugs combination; C Gene set enrichment analysis of AGE-RAGE signaling pathway comparing SKM-1 cells treated VEM and drugs combination; D Gene set enrichment analysis of HIPPO signaling pathway comparing SKM-1 cells treated with BOR, VEM and drugs combination; E–P Relative expression level of genes in HIPPO signalin pathway (MST1/2, LAST1/2, YAP1, TAZ) was normalized to β-actin in AML cell lines by RT-qPCR; Q&S, Expressions of the genes in HIPPO signalin pathway (MST2, YAP1, TAZ) were detected in SKM-1 cells by western blot, β-actin was used as a loading control; R&T Expressions of the genes in HIPPO signalin pathway (MST2, YAP1, TAZ) were detected in MOLM-13 cells by western blot, β-actin was used as a loading control. *P < .05; **P < .01; ***P < .001; ****P < .001. Data was presented as mean ± SD of three independent experiments

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Biology Direct

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