Skip to main content
Fig. 4 | Biology Direct

Fig. 4

From: Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy

Fig. 4

VEM in combination with BOR induce cellular senescence in AML. A LaminB1 and TRF2 in SKM-1 cells treated by VEM and/or BOR detected by IF; B LaminB1 and TRF2 in SKM-1 cells treated by VEM and/or BOR detected by IF; C–D, VEM in combination with BOR arrested the cell cycle at S phase in AML cells; E–F Expressions of cell cycle related protein (CDK2, CDK4, P16, and P21) were detected by western blot. GAPDH was used as a loading control

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us