Fig. 7

circLRIG1 suppresses bladder carcinoma progression by modulating the miR-214-3p/LRIG1 axis. A Protein level of LRIG1 in bladder carcinoma cell lines (UMUC3 and T24) was determined by Western blot assay after transfection with si-NC or si-LRIG1. B Cell viability of bladder carcinoma cell lines (UMUC3 and T24) was determined by CCK-8 assay after transfection with indicated constructs (OE-vector, OE-circLRIG1, OE-circLRIG1 + miR-214-3p mimics, OE-circLRIG1 + si-LRIG1). C Colony formation assay was used to determine the colony number of cells in (B). D Flow cytometry analysis was used to determine the apoptosis number of cells in (B). E Transwell assay (uncoated with Matrigel) was used to determine the cell migration capability in (B). F Transwell assay (coated with Matrigel) was used to determine the cell invasion capability in (B). G Protein level of E-cadherin, N-cadherin, and Vimentin was determined by Western blot assay in (B). The experiment was performed in triplicate. ^**P < 0.01, ^{^^}P < 0.01, ^&&P < 0.01