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Fig. 3 | Biology Direct

Fig. 3

From: Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma

Fig. 3

Upregulation of circLRIG1 suppresses cell metastasis in bladder carcinoma. A The number of migrated cells in bladder carcinoma cell lines (UMUC3 and T24) after transfection with OE-vector or OE-circLRIG1 plasmids was determined using the wound healing assay. B The cell migration capability in (A) was determined using the Transwell assay (uncoated with Matrigel). C The cell invasion capability in (A) was determined using the Transwell assay (coated with Matrigel). D The protein levels of E-cadherin, N-cadherin, and Vimentin in bladder carcinoma cell lines (UMUC3 and T24) after transfection with OE-vector or OE-circLRIG1 plasmids were determined using the Western blot assay. E The number of lung metastatic nodules was determined using H&E staining. F The number of lung metastatic nodules was counted.The experiment was performed in triplicate. “**” indicates P < 0.01

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