Fig. 6

Apoe knockout suppresses GFAP expression in the spinal dorsal horn of the complete Freund’s adjuvant (CFA)-induced inflammatory pain mouse model. Representative images (A) and quantification (B, C) of GFAP-positive signals in the superficial dorsal horn on the ipsilateral (Ipsi) (B) and contralateral (Contra) sides (C). N = 3 mice/group (6–10 sections/mouse). ^****p < 0.0001 compared with physiological saline-treated C57BL6 (C57) mice, ^####p < 0.0001 compared with CFA-treated C57 mice. Two-way analysis of variance, followed by Tukey’s post-hoc test