Fig. 5

Apoe knockout suppresses the complete Freund’s adjuvant (CFA)-induced upregulation of p-Jun in the spinal dorsal horn. Representative images (A) and quantification of p-Jun-positive signals in the superficial dorsal horn (Layers I–III; B, D) and deep dorsal horn (Layers IV–VI; C, E) on the ipsilateral (Ipsi) side (B, C) and the contralateral (Contra) sides (D, E). N = 3 mice/group (5–6 sections/mouse). B ^****p < 0.0001 compared with physiological saline-treated C57BL6 (C57) mice; ^###p = 0.0002 compared with CFA-treated C57 mice. C ^**p = 0.0013 compared with saline-treated C57 mice; ^###p = 0.0006 compared with CFA-treated C57 mice. D ^****p < 0.0001 compared with saline-treated C57 mice; ^####p < 0.0001 compared with CFA-treated C57 mice. E ^***p = 0.0004 compared with saline-treated C57 mice; ^##p = 0.0014 compared with CFA-treated C57 mice. Two-way analysis of variance, followed by Tukey’s post-hoc test