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Fig. 4 | Biology Direct

Fig. 4

From: RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells

Fig. 4

Hedgehog signaling pathway involves in RCC2-mediated prostate cancer cells. A Volcanic map showed the DEGs in RCC2 knockdown DU145 cells compared to control DU145 cells. B Top 8 signaling were selected in RCC2 knockdown DU145 cells compared to control DU145 cells based on NSE analysis. C GSEA analysis showed the Hh signaling pathway was enriched in RCC2 knockdown DU145 cells compared to control DU145 cells. D, E The protein expression of three genes (GLI1, GLI3, and SUFU) involved in the Hh signaling pathway in DU145 and PC3 cells after (D) RCC2 knockdown or (E) overexpression were detected with western blot. F The protein expression of three CSCs markers (SOX2, Nanog, and CD44) in DU145 and PC3 cells after RCC2 knockdown or overexpression were tested with western blot

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Biology Direct

ISSN: 1745-6150

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