Fig. 5

The high-level amplifications of 8p24 characterized a BRCA subtype with poor prognosis. A The high-level amplifications of four miRNAs, including has-miR-30d-3p, has-mir-30b-5p, has-miR-30d-5p and has-miR-151a-3p, were associated with poor prognosis in BRCA. B Schematic diagram of chromosome location of has-miR-30d-3p, has-mir-30b-5p, has-miR-30d-5p and has-miR-151a-3p in BRCAs. C Subgroup clustering SCNAs heatmap of 4 driver miRNAs in BRCA patients. D 8q24 amplification characterized a new BRCA subtype with poor prognosis. E 8q24 amplification subdivided LumA subtype with significant survival differences. F Hallmark signatures significantly were enriched by the dysregulated ceRNA networks of subgroups. G The enrichment scores of proliferation markers were significantly higher in subgroup I compared to subgroups II and III. H Significantly downregulated target genes in subgroup I significantly overlapped with cancer-related genes. I Target network of 43 cancer-related genes regulated by has-mir-30b-5p, has-mir-30d-5p, and has-mir-151a-3p. J The correlation heatmap between the expression of cancer-related genes and the activity levels of proliferation hallmarks. Red points denote positive correlation, blue points denote negative correlation; the point size represents the degree of correlation (*p < 0.05; **p < 0.01; ***p < 0.001, independent Student’s t-test)