Fig. 3

Dynamic target networks of driver miRNAs. A Volcano plot for dysregulated expression (|log (FC)|> log (1.2), FDR < 0.05) of targets were caused by SCNAs of hsa-miR-200c-3p; Green points denote genes with significantly dysregulated expression; Red points denote carcinoma related genes; Grey points denote genes with non-significantly dysregulated expression. B Expression levels of DNMT3B, POLQ, ESPL1, KIF14 and FAM83D were significantly upregulated by heterozygous deletion of has-miR-200c-3p. C The hallmark signatures were significantly enriched by dysregulated expression targets caused by SCNAs of driver miRNAs. D Hsa-mir-30b-5p and hsa-mir-106b-5p intersection of active targets under different copy number states. E The hallmark signatures were significantly enriched by the dysregulated target networks