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Fig. 1 | Biology Direct

Fig. 1

From: ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway

Fig. 1

The downregulation of ACSM5 in LF hypertrophy tissues was significantly correlated with lipid accumulation. (A) RT-qPCR was used to detect the mRNA expression levels of ACSM5 in LF hypertrophy tissue (n = 16) and normal tissue (n = 13). (B) Western blot was used to detect the mRNA expression level of ACSM5 in LF hypertrophy tissue (n = 10) and normal tissue (n = 10). (C) Lipid accumulation in the LF hypertrophy tissue (n = 16) and normal tissue (n = 13) was detected by oil red O staining. Bar size = 100 nm. (D) TG levels in the LF hypertrophy tissue (n = 16) and normal tissue (n = 13) was detected using TG assay kit. (E) Pearson Correlation Coefficient Analysis showed that the expression levels of ACSM5 in LF hypertrophy tissues was negatively correlated with TG levels and lipid accumulation. Ctrl., ligamentum flavum normal tissues. HLF, hypertrophy tissues of ligamentum flavum. TG, triglyceride. ###P < 0.001

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