Fig. 4

Model of the function of uc.291/ACTL6A in normal and psoriasis lesional skin. A In the basal layer (proliferating cells) of normal skin, ACTL6A is required for the inhibition of the expression of the EDC (epidermal differentiation complex) genes. Expression of uc.291 during differentiation of keratinocytes is important to allow the expression of EDC genes by binding and inhibiting ACTL6A. On psoriasis lesional skin (bottom panel), the expression of ACTL6A increases while uc.291 is reduced. As a consequence, the proliferating layer is thicker than in healthy skin and the differentiation process is affected