Fig. 2

Expression of differentiation genes filaggrin and loricrin in normal epidermis and psoriatic non-lesional lesional skin. A Expression of FLG and LOR at the mRNA level. Relative quantification on normal human skin (n = 9), non-lesional (n = 7), and lesional skin (n = 7) was obtained by RT-qPCR. B Bioinformatics analysis of FLG and LOR expression in normal human skin (n = 64) and from non-lesional (n = 54) and lesional (n = 54) areas of skin psoriatic patients (GSE13355). C Immunohistochemistry of Filaggrin in normal human skin (n = 3) and human skin affected by psoriasis (n = 3). Scale bar, 250 μm (left panels) and 100 μm (right panels). A representative experiment of three is shown. For all experiments and datasets analysis of data sets, the p-value was obtained using a t-test student; p < 0.05; n.s. not significant. Replicae are biological replicates