Figure. 1

MiR-31-5p knockout aggravated pain hypersensitivity and activate inflammatory response in mice. a Mechanical withdrawal threshold in WT and miR-31-5p^−/− male mice, ^** P < 0.01, two- tailed unpaired t-test, n = 8 mice. b Heat withdrawal latency in WT and miR-31-5p^−/− male mice, ^** P < 0.01, two- tailed unpaired t-test, n = 8 mice. c Cold withdrawal latency in WT and miR-31-5p^−/− male mice, ^** P < 0.01, two- tailed unpaired t-test, n = 8 mice. d Mechanical withdrawal threshold in WT and miR-31-5p^−/− female mice, ^** P < 0.01, two- tailed unpaired t-test, n = 8 mice. e Heat withdrawal latency in WT and miR-31-5p^−/− female mice, ^** P < 0.01, two- tailed unpaired t-test, n = 8 mice. f Cold withdrawal latency in WT and miR-31-5p^−/− female mice, ^** P < 0.01, two- tailed unpaired t-test, n = 8 mice. RT-qPCR analysis of TNF‐α (g), IL‐6 (h) and IL‐1β (i) expression in the DRG of WT and miR-31-5p^−/− mice. ^**P < 0.01, two- tailed unpaired t-test, n = 6 mice.