Fig. 7
Identification of protective mRNAs in cEVs and nEVs. (A-G). Heat map illustrating the log2 mass abundance values for the mRNA expression enriched in the cEVs and nEVs involved in cardioprotection pathological processes, including antioxidant (A), redox homeostasis (B), glycolysis (C), unfolded protein response (UPR) signaling pathway (D), Ca2+ homeostasis (E), heat shock proteins (HSPs) (F), and AMPK signaling (G). H. PPI network showing the top 10 hub genes involved in the above cardioprotection pathological processes. I. Relative expression of hub top 9 genes (Gapdh was excluded) in cEVs and nEVs. J. Relative expression of the top 9 hub genes (Gapdh was excluded) in mice hearts with different treatments 1 day after MI (n = 4). K. ROS production in mice hearts of different groups 1 day after MI was indicated by DHE staining (scale bar = 50 μm, n = 4). L. ATP content in mice hearts of different groups 1 day after MI (n = 5). (****P < 0.001, ***P < 0.01 for MI + cEVs group or MI + nEVs group vs. MI + PBS group; ###P < 0.01, ##P < 0.05 for MI + nEVs group vs. MI + cEVs group)