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Fig. 1 | Biology Direct

Fig. 1

From: Extracellular vesicles derived from different tissues attenuate cardiac dysfunction in murine MI models

Fig. 1

Characterization of cEVs and nEVs. (A) NTA analysis of the diameter of cEVs and nEVs. (B) Representative TEM micrographs of cEVs and nEVs (scale bar = 100 nm). (C) Representative light scattering microscopy (LSM) images of cEVs and nEVs. (D) Protein analysis of the EVs markers (Tsg 101, Alix, and Calnexin). (E) H&E staining of heart tissue from different groups to assess the biosafety of intramyocardial injection of cEVs and nEVs in vivo. Scar bar:100 μm. (F) Relative mRNA expressions of IL-1β, IL-6, TGF-α, and IL-10 in mice hearts among different groups. (*P < 0.05, ***P < 0.001 for MI + cEVs group or MI + nEVs group vs. Sham group; #P < 0.05, ###P < 0.001 for MI + cEVs group or MI + nEVs group vs. PBS group; &&&P < 0.001 for MI + nEVs group vs. MI + cEVs group)

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Biology Direct

ISSN: 1745-6150

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