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Fig. 3 | Biology Direct

Fig. 3

From: Long noncoding RNA KCNMA1-AS1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the SMAD9 signaling pathway

Fig. 3

KCNMA1-AS1 promotes in vivo bone formation from hBMSCs. A- Xenograft tissue removed from the nude mice. B- Representative Micro CT scanning images of xenograft tissues. Scale bar, 500 μm. C-G- Bone volume or tissue volume (BV/TV) (C), bone surface/ tissue volume (BS/TV) (D), trabecular thickness (Tb.Th) (E), trabecular number (Tb.N) (F) and bone mineral density (BMD) (G) analyzed in xenograft tissues. H and I- HE staining (H) and Masson’s trichrome staining (I) of xenograft tissues. Scale bar, 50 μm. J-L- The expression levels of COL1A1 (J), RUNX2 (K), and OPN (L) in xenograft tissues evaluated by immunohistochemistry. Scale bar, 50 μm. *P < 0.05, **P < 0.01, in comparison to NC/sh-NC.

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