Fig. 7

Power Spectral Density. a–e. Comparison of topographic distribution of EEG Power Spectral Density before vs after intranasal NGF administration showed a mean cumulative increase of slow and organized rhythms at the expense of fast and disorganized ones. Blue coloring corresponds to a better expression of waves in post treatment EEG, despite to a red shades that indicate a wider expression in pretreatment pathways. In particular: diffuse increase of theta activity, mainly evident on the midline regions (a); diffuse increase of alfa activity, particularly evident on the parieto-occipital regions (b); improvements in delta waves mainly in Broadman areas and limbic region with cingulum zone (c); diffuse decrease of beta activity, which does not occur on the left on the parieto-occipital regions (d); diffuse decrease of gamma activity, particularly evident in parietal-midline areas (e)