Fig. 6

T-MSCs alleviate DSS-induced colitis in a NO production-dependent manner. (A) Pattern diagram of DSS-induced colitis in mice prevented by tail vein injection of T-MSCs. (B, C) Body weight and colon length of IBD mice treated with phosphate-buffered saline (PBS), T-MSCs, and Nos2^−/− T-MSCs on day 2 post-IBD induction (B, C, n = 6–9). (D) Representative H&E-stained colon sections and histological scores of IBD mice treated with PBS, T-MSCs, and Nos2^−/− T-MSCs on day 2 post-IBD induction (n = 6). Scale bars, 100 μm. (E) IL-6 in the serum of IBD mice treated with PBS, T-MSCs, and Nos2^−/− T-MSCs on day 2 post-IBD induction was assayed by enzyme linked immunosorbent assay (ELISA) (n = 6–8). Data are represented as mean ± SEM. *p < 0.05, ***p < 0.001, ****p < 0.0001