Biological roles of RNA m7G modification and its implications in cancer

Biology Direct

Table 2 Drug resistance in cancer mediated by m7G regulators

m7G regulators	Tumors	Drug	Function	mechanism	References
METTL1	Colon cancer	Cisplatin	Increase drug sensitivity	Regulate miR149-3p/S100A4/P53 axis	[106]
METTL1, WDR4	Hepatocellular carcinoma	Lenvatinib	Decrease drug sensitivity	Promote the translation of EGFR	[107]
METTL1	Nasopharyngeal carcinoma	Cisplatin and Docetaxel	Decrease drug sensitivity	Activate WNT/β- catenins/EMT pathway	[76]
WDR4	Hepatocellular carcinoma	Sorafenib	Decrease drug sensitivity	Promote the translation of CCNB1	[11]
METTL1	Cervical cancer	5-Fluorouracil	Decrease drug sensitivity	Lead to rapid tRNA(Val^AAC) decay	[108]
WBSCR22	Colon cancer	oxaliplatin	Decrease drug sensitivity	Reduce intracellular ROS and 8-oxoG	[55]

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