Fig. 2
From: Biological roles of RNA m7G modification and its implications in cancer
The process and location of m7G modifications in RNA. m7G modifications are present at the 5’cap, 5’UTR and A-G rich regions of mRNA. Where methylation at the 5’cap is mediated by RNMT/RAM, methylation within the mRNA is mediated by METTL1/WDR4. METTL1/WDR4 is the enzyme that catalyzes m7G methylation at the tRNA G46 position. The methyltransferase WBSCR22/TRMT112 catalyzes the 18s rRNA G1639 site