Fig. 3
From: Preliminary insights into RNA in CSF of pediatric SMA patients after 6 months of nusinersen
Principal component analysis (PCA) of DE cfRNAs in “all” SMA patients at T6 versus T0. PC1: 24.3 (x-axis) and PC2: 21.8 (y-axis). Samples at T0 are colored in green, while T6 samples are colored in orange. Interestingly, a subset of patients at T6 appeared to cluster less in terms of gene expression pattern. Thus, we separated these samples in the following analyses, defining them as “heterogeneous” group. Samples that did not show this pattern alteration will be described as “homogeneous”